A new round of menacing and mutated new coronaviruses has plunged the world into a state of large-scale emergency prevention and control. I believe that the most discussed thing recently is that everyone will be concerned: Have you been vaccinated? Recently, this needle can be said to be squeezed and it is difficult to make an appointment.
Recently, there is good news. Chen Wei, a researcher at the Academy of Military Sciences, vice chairman of the China Association for Science and Technology, and academician of the Chinese Academy of Engineering, revealed that the aerosol inhaled new crown vaccine developed by the team has been approved by the Food and Drug Administration for expanded clinical trials, and is now applying for emergency use. . It means that the 'no injection' new crown vaccine will be popularized in a short period of time in the future, the speed of vaccination will be greatly accelerated, and the coverage rate will be greater.
Compared with injected vaccines, the advantages of aerosol inhaled vaccines are obvious
1. The dosage of the drug is small, and the dosage is only about one-fifth of the injection vaccine, and no bottled is required, which relieves the tension of bottled and reduces the pressure of logistics and transportation.
2 and 3 immunizations are better than injections. Atomized inhalation vaccines can directly atomize the vaccine into fine particles through a nebulizer. Through deep inhalation, the vaccine particles can be directly inhaled into the respiratory tract and lungs, and the vaccine is in the respiratory mucosa and alveoli. The immune response of the mucosa is stimulated internally, which can cause three immune effects: mucosal immunity + cellular immunity + humoral immunity, and the protection effect is better. This triple immunity is the most ideal state.
3. The immune effect is fast and the side effects are small. After atomization inhalation, it can quickly take effect in the nasal cavity, throat, trachea, alveoli, mucous membranes and other parts. The phenomenon of redness, swelling and allergy in the injected part will also disappear due to atomization inhalation. .
4. The popularity of immunization is high. Compared with injections, inhaled vaccines are painless and more accessible. It is very convenient for people who are 'afraid of needles' and 'stunned by needles.' easier to accept.
5. Simple and convenient, you can take it for inhalation at any time, no special conditions are required for storage, and there is no requirement for inoculation. At the moment of mass inoculation, the daily inoculation task is very large. If inhalation is used, it will save a lot of manpower and material resources, which is more convenient and fast. , which is more maneuverable and more suitable for large-scale inoculation.
Nebulized vaccine stimulates mucosal immunity
It is reported that the aerosol inhaled new crown vaccine simulates the natural infection route of the new coronavirus, and can activate local mucosal immunity, cellular immunity and humoral immunity to achieve the purpose of eliminating the virus and preventing infection. It is the same as the recombinant new crown vaccine that has been approved for marketing with conditions before, in the virus seed, cell bank, stock solution production process, preparation production process, preparation formula, etc. It is only used for immunization with a special device for atomization inhalation immunization, so that Aerosolized vaccine tiny particles enter the human respiratory tract and lungs.
In a word, compared with the fact that the injection of the vaccine can cause humoral immunity (produce antibodies to kill the new coronavirus) and cellular immunity (immune cells kill the new coronavirus), the actual benefit of the aerosol inhaled new crown vaccine is that it provides additional mucosal immunity. An extra layer of protection.
Therefore, the aerosol inhaled new crown vaccine is equivalent to an additional line of defense, which is strongly resisted when the virus invades the human body. If there are still fish that slip through the net into the human body, they can be further eliminated through cellular immunity and humoral immunity.
In addition to aerosol inhalation vaccines, for some diseases, aerosol inhalation is also very suitable
In clinical practice, aerosol inhalation is a very common method. The onset of action of the drug is very fast, and the local drug concentration is very high, and the dosage is about one-tenth of the oral dosage, which means that the patient's dosage will be very small each time, even a small amount of medication can play a good role. Effect.
At the same time, it rarely causes systemic adverse reactions, which are the characteristics of aerosol inhalation drugs and are widely used in respiratory diseases. For example, asthma, bronchitis, cough, expectoration, dyspnea, and laryngitis.
In addition to aerosol inhalation vaccines, for some diseases, aerosol inhalation is also very suitable
In clinical practice, aerosol inhalation is a very common method. The onset of action of the drug is very fast, and the local drug concentration is very high, and the dosage is about one-tenth of the oral dosage, which means that the patient's dosage will be very small each time, even a small amount of medication can play a good role. Effect.
At the same time, it rarely causes systemic adverse reactions, which are the characteristics of aerosol inhalation drugs and are widely used in respiratory diseases. For example, asthma, bronchitis, cough, expectoration, dyspnea, and laryngitis.
In addition to the preventive measures advocated by the state, such as not gathering, wearing masks, washing hands frequently, and strict protection, timely injection of the new crown vaccine has established a solid barrier to prevent the spread of the new crown virus. At present, the latest aerosol inhalation new crown vaccine released by my country in the world is also urgently put into trials.