“Aerosol administration alongside non-invasive ventilation (NIV) is now a common clinical delivery method, but the efficiency of delivery varies between different delivery devices.”
[1] Mesh nebulizer versus jet nebulizer for lung deposition rates during NIV
In this study, subjects inhaled 99mTc-DTPA (25 mCi/3 mL) labelled salbutamol 2.5 mg, ipratropium bromide 0.25 mg and 0.9% physiological saline using a mesh nebulizer and a mesh nebulizer and jet nebulizer respectively, timed to nebulize for 1 minute from the start of the spray or until there was no visible aerosol (whichever occurred first), and lung was assessed using planar scintigraphy Assessment of aerosol deposition using planar scintigraphy.
(A: Jet nebulizer; B: Mesh nebulizer)
[1] The results found that nebulized drug delivery during NIV was significantly more effective using a net nebulizer compared to a jet nebulizer, with significant image contrast.
[2] Mesh nebulizer versus Jet nebulizer and pMDI for drug delivery efficiency during non-invasive ventilation
In this study, the investigators investigated the efficiency of drug delivery using a mesh nebulizer, a jet nebulizer and a pMDI, respectively, applying different NIV masks in a simulated adult lung model.
Salbutamol sulphate (2.5 mg/3 ml) was nebulized in a mesh nebulizer and a jet nebulizer and pMDI was sprayed 4 times (108 ug/puff). The drug was eluted from the filter and analysed UV spectrophotometrically at 276 nm.
Drug delivery systems
[2] The results found that the use of nebulizing devices and masks affected the efficiency of drug delivery in a simulated adult lung model. The mesh nebulizer delivered approximately 7 times more dose than the pMDI and approximately 2 times more than the jet nebulizer.
In summary: the mesh nebulizer is clearly superior to the jet nebulizer on both criteria of lung deposition rate and drug delivery efficiency.
References
[1]Galindo-Filho VC, Ramos ME, Rattes CSF, et al. Radioaerosol pulmonary deposition using mesh and jet nebulizers during noninvasive ventilation in healthy subjects. Respir Care. 2015;60(9):1238-1246
[2]AlQuaimi MM, Fink JB, Ari A. Efficiency of different aerosol devices and masks during noninvasive positive pressure ventilation in a simulated adult lung model. J Respir Med Lung Dis. 2017;2(3):1018.